Bladder Cancer Xenograft Models Available

Several PDX models are available for bladder cancer, including xenografts that are muscle-invasive.  These models all follow the overall structure and morphology of the source human tumors when engrafted at a low passage number into immunocompromised mice.

Request formal project quotation from Altogen Labs CRO.

Tumor Type Mutations Comments
Urothelial Carcinoma TP53 TP53, ATM, FLT3, PTPN11
Urothelial Carcinoma invasive

TP53—tumor suppressor p53: Mutations in p53 lead to genomic instability and lower sensitivity to DNA damaging agents.

ATM—ataxia-telangiectasia mutated: Plays a central role in response to chemical and ionizing-radiation induced DNA damage. Mutations in ATM increase sensitivity to ionizing radiation.

Click here to request bladder cancer xenograft project quote from Altogen Labs CRO.